Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds from Persicaria hydropiper L.

  title={Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds from Persicaria hydropiper L.},
  author={Muhammad Mazhar Ayaz and Abdul Sadiq and Osama F. Mosa and Tariq A Zafar and Alashary Adam Eisa Hamdoon and Modawy Elnour Modawy Elkhalifa and Mohammed Ahmed Elawad and Alshebli Ahmed and Farhat Ullah and Mehreen Ghufran and Atul Kabra},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  • M. AyazA. Sadiq A. Kabra
  • Published 14 April 2022
  • Biology, Chemistry
  • Evidence-based Complementary and Alternative Medicine : eCAM
Introduction Natural products are among the most useful sources for the discovery of new drugs against various diseases. Keeping in view the ethnobotanical relevance ethnopharmacological significance of Polygonaceae family in diabetes, the current study was designed to isolate pure compounds from Persicaria hydropiper L. leaves and evaluate their in vitro and in silico antidiabetic potentials. Methods Six compounds were isolated from the chloroform-ethyl acetate fractions using gravity column… 
4 Citations

Figures and Tables from this paper

New lead compounds identification against KRas mediated cancers through pharmacophore-based virtual screening and in vitro assays.

Computer-aided drug designing approaches as well as experimental methods were employed to find new and potential anti-cancer drugs and showed that small lead compound inhibitors were identified to inhibit the activity of this protein by blocking the GTP-binding pocket.

Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection

Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way

Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks

The concomitant use of the majority of herbal medicines with chemotherapy has been demonstrated to be beneficial in multiple malignant tumors, however, herbal medicines which possess positive interaction and improve the quality of life of patients should be sorted out and integrated with the chemotherapy.



Treating Hyperglycemia From Eryngium caeruleum M. Bieb: In-vitro α-Glucosidase, Antioxidant, in-vivo Antidiabetic and Molecular Docking-Based Approaches

It is concluded that Eryngium caeruleum is a potential source of bioactive compounds which may be beneficial for the management of ailments like diabetes and free radicals mediated disorders.

Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study

In the current study, essential oils from leaves and flowers of P. hydropiper exhibited dose dependent anticholinesterase and antioxidant activities and can be subjected to further in-vitro and in- vivo anti-Alzheimer’s studies.

In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

The results showed that the semi alcoholic extract of the two studied plants possess α-glucosidase inhibitory activity, antioxidant potency, and low antibacterial effect.

Cytotoxicity, anti-angiogenic, anti-tumor and molecular docking studies on phytochemicals isolated from Polygonum hydropiper L.

Docking analysis suggests that Polygonum hydropiper not only has the ability to bind to EGFR and HER2 but also equally binds to VEGFR and may act as potential anti-angiogenic agents.

Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities

Four of the nine isolated compounds exhibited strong inhibitory activity with IC50 values below 8 µM, much higher than acarbose (377 uM).

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots

It is demonstrated that among the compounds isolated from CH2Cl2 fraction of F. bracteata roots, coumarins were determined as the main chemical constituents of this fraction, the first report on isolation and characterization of the bioactive compounds from root extracts of Ferulago bractedeata.

Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

β-sitosterol is a potential compound for the management of memory deficit disorders like AD and behavioral and molecular docking studies support the possibility as a potential anti-Alzheimer's agent.

A preliminary evaluation of cytotoxicity, antihyperglycemic and antinociceptive activity of Polygonum hydropiper L. ethanolic leaf extract

The results of the present study showed that Polygonum hydropiper L. ethanolic leaf extract possess antihyperglycemic and antinociceptive activity which could justify its ethnomedical use.