Antioedematogenic effect of marrubiin obtained from Marrubium vulgare.

@article{Stulzer2006AntioedematogenicEO,
  title={Antioedematogenic effect of marrubiin obtained from Marrubium vulgare.},
  author={H. K. Stulzer and M. P. Tagliari and J. A. Zampirolo and V. Cechinel-Filho and V. Schlemper},
  journal={Journal of ethnopharmacology},
  year={2006},
  volume={108 3},
  pages={
          379-84
        }
}
This paper describes the antioedematogenic profile of marrubiin (1), the main constituent of Marrubium vulgare, a medicinal plant used in folk medicine of several countries to treat different pathologies. Compound (1) was analyzed in a model of microvascular leakage in mice ears. The results show that it exhibits significant and dose-related antioedematogenic effects. The results obtained for ID50 values (mg/kg, i.p.) and maximal inhibition (%) for the different phlogistic agents used were as… Expand
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The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid, which has been designated as marrubic acid, that exhibited a significant antihepatotoxic activity and increased total protein levels. Expand
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The results suggest that marrubiin, like hydroalcoholic extract of M. vulgare, does not interact with opioid systems, and is more potent than some well-known analgesic drugs. Expand
Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae).
TLDR
Marrubiin, a furane labdane diterpene, is the main analgesic compound present in Marrubium vulgare, a medicinal plant used in Brazil and other countries to treat several ailments, suggesting its possible use as a model to obtain new and potent analgesic agents. Expand
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