Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats

@article{Roth2008AntiobesityEO,
  title={Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats},
  author={Jonathan David Roth and James L Trevaskis and Julie Wilson and Chunli Lei and Jennifer R Athanacio and Cara Mack and Nicole C. Kesty and Todd Coffey and Christian Weyer and David G. Parkes},
  journal={International Journal of Obesity},
  year={2008},
  volume={32},
  pages={1201-1210}
}
Objective:To characterize the interactive effects of amylin with phentermine or sibutramine on food intake, body weight/composition and gene expression in diet-induced obese (DIO) rats.Design:DIO rats were intraperitoneally injected with a single dose of amylin (10 μg kg−1) and/or phentermine (1 mg kg−1) or chronically infused with amylin (100 μg kg−1 d−1) or vehicle with or without phentermine (0.5–10 mg kg−1 d−1) or sibutramine (3 mg kg−1 d−1) using two surgically implanted subcutaneous… CONTINUE READING