Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

@article{Mashiko2005AntiobesityEO,
  title={Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.},
  author={Satoshi Mashiko and Akane Ishihara and Akira Gomori and Ryuichi Moriya and Makoto Ito and Hisashi Iwaasa and Masao Matsuda and Yue Feng and Zhu Shen and Donald J. Marsh and Maria A. Bednarek and Douglas J Macneil and Akio Kanatani},
  journal={Endocrinology},
  year={2005},
  volume={146 7},
  pages={3080-6}
}
Melanin-concentrating hormone (MCH) is a cyclic orexigenic peptide expressed in the lateral hypothalamus, which plays an important role in regulating energy balance. To elucidate the physiological role of MCH in obesity development, the present study examined the effect of a selective MCH1 receptor (MCH1R) antagonist in the diet-induced obesity mouse model. The MCH1R antagonist has high affinity and selectivity for MCH-1R and potently inhibits intracerebroventricularly injected MCH-induced food… CONTINUE READING

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  • M Narita, K Mizuno, M Shibasaki, T Suzuki
  • Neuroscience
  • 2002

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