Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial

  title={Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial},
  author={Soo-Hyun Park and T.-L. Huh and Sun-Young Kim and Mi-Ra Oh and Pichiah Balasubramanian Tirupathi Pichiah and Soo-Wan Chae and Youn-Soo Cha},
The effects of actiponin was investigated, a heat‐processed Gynostemma pentaphyllum extract, on body weight, fat loss, and metabolic markers of Korean participants in a 12‐week, randomized, double‐blind, placebo‐controlled clinical trial. 
A Systematic review and Meta-analysis efficacy of Gynostemma pentaphyllum (Thunb.) Markino on Blood glucose, lipid profile, blood pressure and anthropometric parameters
This study suggests that G. pentaphyllum can be used as an alternative for glycemic control, however, the adverse side effect and safety should be concerned and a randomized control trial is still needed in order to confirm other clinical outcomes and safety.
Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats
GP maintained intestinal integrity and reversed gut dysbiosis in high-fat diet (HFD)-induced NAFLD rats, which reduced the ratio of Firmicutes to Bacteroidetes, enriching the abundance of beneficial bacteria and inhibiting the Plenty of pathogenic bacteria in the gut.
Caco-2 Cell Permeability of Flavonoids and Saponins from Gynostemma pentaphyllum: the Immortal Herb
This study predicts the potential oral bioavailability of nine dammarane saponins and five flavonol glycosides from G. pentaphyllum using the Caco-2 cell monolayer permeability model and indicates that a higher degree of glycosylation-facilitated permeability is suggestive of active transport.
Gynostemma pentaphyllum (Thunb.) Makino (Cucurbitaceae) – A New Record for Karnataka
Gynostemma pentaphyllum (Thunb.) Makino, a herbaceous vine of the family Cucurbitaceae is reported here as new record for Karnataka state.
Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials
Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome.
Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials
To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and meta‐analysis of herbal medicines for weight loss.
Exploring Phytotherapeutic Alternatives for Obesity, Insulin Resistance and Diabetes Mellitus.
This review comprises an exploration of currently available preclinical and clinical research on the role of MH in the management of obesity, IR, and DM.
APOE and CETP TaqIB polymorphisms influence metabolic responses to Hibiscus sabdariffa L. and Gynostemma pentaphyllum Makino tea consumption in hypercholesterolemic subjects.
Investigating the effects of HS and GP tea consumption on anthropometric data, fasting blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms concluded that HS consumption may have beneficial effects with respect to TG concentrations in the B2 carriers, but it may adversely affect HDL-C concentrations in homozygous B1B1 and E4 carriers.


Chemistry and Pharmacology of Gynostemma pentaphyllum
In vitro and in vivo evidence suggests that Gynostemma pentaphyllum may complement the popular herbal medicine, Panax ginseng, as it also contains a high ginsenoside content and exhibits similar biological activities.
Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase
The results demonstrate the beneficial effect of G. pentaphyllum on improving obesity and have elucidated the underlying molecular mechanisms.
Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.
G cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo and was not influenced by treatment group.
Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice.
The results suggest that the supplementation of high-dose GPE (0.01%) in the diet lowers the blood glucose level by altering the hepatic glucose metabolic enzyme activities.
Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat.
  • Samer Megalli, N. Davies, B. Roufogalis
  • Biology
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2006
The improvement in glucose tolerance at 120 min by Gynostemma pentaphyllum in obese Zucker fatty rats but not lean rats suggests that it may improve insulin receptor sensitivity and together with the significant reduction of hypertriglyceridemia, cholesterol and low density lipoprotein cholesterol suggests that Gynstemma should be examined further by oral hypoglycemic/anti-hyperlipidemic therapy.
Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial
Ten weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet, although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis.
High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis.
First clinical studies with orlistat: a short review.
Orlistat, a lipase inhibitor, in a dose of 50 mg three times a day leads to a significant increase in weight loss compared to placebo in moderately obese people and is tolerated very well, although a higher occurrence of gastrointestinal side effects is seen.
Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial.
It is suggested that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention.