Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.

@article{Chang2011AntiobesityAO,
  title={Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.},
  author={Hsiao-Pei Chang and Mei-lin Wang and M. Chan and Yen-Shuo Chiu and Yue-Hwa Chen},
  journal={Nutrition},
  year={2011},
  volume={27 4},
  pages={463-70}
}
OBJECTIVE This study investigated the effects of indole-3-carbinol (I3C), a cruciferous vegetable derivative, on obesity and its associated factors in high-fat-diet-induced obese (DIO) mice. METHODS Eighteen male C57BL/6 mice were randomly assigned to one of three groups: basal, high fat (HF), and HF + 5 mg/kg of I3C intraperitoneally (HFI). After 12 wk of treatment, obesity-associated factors, including body weight, organ weight, serum concentrations of glucose, triacylglycerol, insulin, and… CONTINUE READING
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