Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats.

Abstract

Antinociceptive effects of a new water-soluble sedative agent, an isoindolin-1-one derivative, (-)-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f]isoindol-1-(2H)-one (JM 1232 (-)) were studied in two different nociceptive models of rats. Sprague-Dawley rats with lumbar intrathecal catheters were tested for their thermal… (More)
DOI: 10.1016/j.ejphar.2008.07.054

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