Antinociceptive properties of intrathecal dexmedetomidine in rats.

@article{Fisher1991AntinociceptivePO,
  title={Antinociceptive properties of intrathecal dexmedetomidine in rats.},
  author={Brock Fisher and Mark H. Zornow and Tony L. Yaksh and Bradley M. Peterson},
  journal={European journal of pharmacology},
  year={1991},
  volume={192 2},
  pages={221-5}
}
Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist. In this study, the intrathecal administration of dexmedetomidine into the rat lumbar subarachnoid space produced dose-dependent, prolonged antinociception as measured by hot plate and tail flick testing. Intrathecal administration of 3 or 10 micrograms of dexmedetomidine increased hot plate and tail flick latencies to cutoff values within 15 min of injection. Animals receiving 1 microgram of intrathecal dexmedetomidine did not… CONTINUE READING