Antinociceptive properties of coumarins, steroid and dihydrostyryl-2-pyrones from Polygala sabulosa (Polygalaceae) in mice.

@article{Meotti2006AntinociceptivePO,
  title={Antinociceptive properties of coumarins, steroid and dihydrostyryl-2-pyrones from Polygala sabulosa (Polygalaceae) in mice.},
  author={Fl{\'a}via Carla Meotti and Juliana Vargas Ardenghi and Juliana B Pretto and M{\'a}rcia Maria de Souza and Jana{\'i}na d' Avila Moura and Anildo Cunha J{\'u}nior and Cristian Soldi and Moacir Geraldo Pizzolatti and Adair Roberto Soares dos Santos},
  journal={The Journal of pharmacy and pharmacology},
  year={2006},
  volume={58 1},
  pages={107-12}
}
We have investigated the possible antinociceptive action of the extract, fractions and pure compounds obtained from the whole plant Polygala sabulosa A. W. Bennett (Polygalaceae) in acetic acid-induced visceral pain in mice. Intraperitoneal injection of animals with the hydroalcoholic extract and fractions (CH(2)Cl(2), EtOAc, n-BuOH, aqueous fraction) (1-100 mg kg(-1)) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The CH(2)Cl(2… CONTINUE READING

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