Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test

@article{Ocvirk2008AntinociceptivePO,
  title={Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test},
  author={Rok Ocvirk and Beverley E. Pearson Murphy and Keith B. J. Franklin and Frances V. Abbott},
  journal={PAIN},
  year={2008},
  volume={138},
  pages={402-409}
}
&NA; The present study investigated the effect of acute systemic administration of six progesterone metabolites on formalin‐induced pain in the rat. The 3α‐hydroxylated metabolites allopregnanolone and pregnanolone are highly potent positive modulators at the GABAA receptor and produced a biphasic effect on pain in the formalin test. Dose‐dependent antinociception was observed at lower doses (maximal antinociception at 0.16 mg/kg) and was reversed at higher doses. Bicuculline abolished the… Expand
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