Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.

@article{Ossipov1989AntinociceptiveIB,
  title={Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.},
  author={Michael H. Ossipov and Lauren Su{\'a}rez and Theodore Spaulding},
  journal={Anesthesia and analgesia},
  year={1989},
  volume={68 3},
  pages={194-200}
}
This study was undertaken to evaluate the antinociceptive interactions of alpha 2 adrenergic and opiate receptors at the spinal level. Morphine and clonidine were administered intrathecally (i.t.) by lumbar puncture to rats either alone or in the presence of either i.t. yohimbine, an alpha 2 antagonist, or systemic naloxone, an opioid antagonist. The effect of tolerance to systematically administered morphine on responses to i.t. morphine and clonidine was examined in mice. Antinociception was… CONTINUE READING