Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain.

@article{Xu2011AntinociceptiveEO,
  title={Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain.},
  author={Fangzhou Xu and Shongzhou Xu and Lijun Wang and Chuntao Chen and Xueqing Zhou and Yuzhen Lu and Huihui Zhang},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 9},
  pages={1377-82}
}
Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. It was shown that oral administarion of verticinone could significantly inhibit acetic acid-induced writhing response in a dose-dependent way, and the writhing inhibition of 3 mg/kg verticinone was 66.2%, which was approximately higher than that of 200 mg/kg aspirin. In the formalin test, a high dose of… CONTINUE READING