Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.

@article{Wang2018AntinociceptiveEO,
  title={Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.},
  author={Pei Wang and Ting Ting Zheng and Mengna Zhang and Biao Xu and Run Zhang and Ting Zhang and Weidong Zhao and Xuerui Shi and Qinqin Zhang and Quan Fang},
  journal={Brain research bulletin},
  year={2018},
  volume={139},
  pages={48-55}
}
Cannabinoids (CBs) play important roles in pain modulation. Recently, VD-hemopressin(β) [VD-Hpβ], a 12-residue β-hemoglobin-derived peptide, was reported to activate both CB1 and CB2 receptors in vitro. To further characterize in vivo actions of VD-Hpβ, its antinociceptive activity and site(s) were evaluated in the mouse tail-flick test, and supraspinal… CONTINUE READING