Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception

@article{Katsuyama2011AntinociceptiveEO,
  title={Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception},
  author={Soh Katsuyama and Hirokazu Mizoguchi and Takaaki Komatsu and Chikai Sakurada and Minoru Tsuzuki and Shinobu Sakurada and Tsukasa Sakurada},
  journal={Peptides},
  year={2011},
  volume={32},
  pages={1530-1535}
}
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide (NOP) receptors, has been shown to be metabolized into some fragments. We examined to determine whether intrathecal (i.t.) N/OFQ (1-13), (1-11) and (1-7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin. The i.t. administration of N/OFQ (0.3-1.2 nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response. The N-terminal… 
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