Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception

  title={Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception},
  author={Soh Katsuyama and Hirokazu Mizoguchi and Takaaki Komatsu and Chikai Sakurada and Minoru Tsuzuki and Shinobu Sakurada and Tsukasa Sakurada},
Behavioral Effects of Continuously Administered Bergamot Essential Oil on Mice With Partial Sciatic Nerve Ligation
It is reported that the two-dimensional planar activity significantly increased in mice with PSNL in the light phase but not in the dark phase from the second day after surgery, indicating that BEO exhibits an analgesic action, which is mediated by opioid receptors and not by the olfactory system.
Non-Opioid Peptides Targeting Opioid Effects.
This short review is a compendium of knowledge about the most important and recent findings regarding selected peptides and their modulatory effects on various opioid actions, including cardiovascular and respiratory responses.
Distinct Reactivity of Transient Receptor Potential Vanilloid Subtype 1 in a Murine Model of Atopic Dermatitis with Serious Scratching
Pain responses to heat, acidic stimulation, and capsaicin injection, which are transduced through TRPV1, were decreased in NC/Tnd mice, when compared to two standard strains BALB/c and C57BL/6 mice.
The nociceptin/orphanin FQ receptor system as a target to alleviate cancer‐induced bone pain in rats: Model validation and pharmacological evaluation
The analgesic potential of NOP receptor activation in a rodent cancer‐induced bone pain model is investigated and broad analgesic properties in Nociceptin/orphanin FQ peptide (NOP) receptor agonists are demonstrated.
Expression patterns of nociceptin in rats following experimental tooth movement.
The expression levels of nociceptin were elevated following experimental tooth movement due to bilateral innervation of anterior teeth and bilateral projection of nerve fibers, and the expression levels were similar between ipsilateral and contralateral sides.
Lactobacillus reuteri effects on maternal separation stress in newborn mice
Newborn mice with maternal separation stress have reduced USVs, compared to newborn mice without stress, indicating USV calls may represent “physiological calling” instead of “crying,” and mouse ultrasonic vocalization (USV) call patterns were defined, which will be important in guiding future studies in other mouse strains.
Microwave-Assisted Extraction of Capsaicin from Chili Pepper Powder
The extraction of capsaicin from chili pepper powder by microwave-assisted technique has been investigated in a microwave chemical synthesis instrument. Orthogonal test was conducted on the basis of


Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
  • M. Ko, N. Naughton
  • Biology, Medicine
    The journal of pain : official journal of the American Pain Society
  • 2009
Pharmacological characterization of orphanin FQ/nociceptin and its fragments.
The results suggest that OFQ/N elicits both analgesia and hyperalgesia through pharmacologically distinct receptors that do not correspond to traditional opioid receptors.
Orphanin FQ acts as a supraspinal, but not a spinal, anti‐opioid peptide
The findings indicate that the anti-opioid actions of OFQ are restricted to supraspinal central nervous system sites, and not to systemic morphine antinociception induced by i.c.t. morphine.