Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats.

@article{Vale2003AntinociceptiveEO,
  title={Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats.},
  author={Mariana Lima Vale and Jaciara B Marques and Camila Alencar Moreira and Francisco Airton Castro Rocha and S{\'e}rgio Henrique Ferreira and Stephen Poole and Fernando Q Cunha and Ronaldo de Albuquerque Ribeiro},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 1},
  pages={102-8}
}
The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1-5 ng/animal), IL-10 (0.4-10 ng/animal), or IL-13 (0.4-2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53-89%) or zymosan (63-74%) in mice, and the knee joint incapacitation induced by i.a. injection of zymosan (49-66%) in rats. Neither of the cytokines affected the… CONTINUE READING

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