Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.

@article{Brandt2001AntinociceptiveEO,
  title={Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.},
  author={Michael R. Brandt and M Scott Furness and Nancy K. Mello and Kenner C. Rice and S. Stevens Negus},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={296 3},
  pages={939-46}
}
The effects of SNC80 and other structurally related delta-opioid receptor agonists were assessed under conditions of chemically induced hypersensitivity to thermal stimuli in four rhesus monkeys. The shaved tail of each monkey was exposed to warm water (38, 42, 46, and 50 degrees C), and the tail-withdrawal latency from each temperature was recorded. The effects of drugs on the temperature that produced a 10-s tail-withdrawal latency (the T(10) value) were examined. Capsaicin (0.01-0.32 mg… CONTINUE READING