Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.

@article{Zhang2015AntinociceptiveEO,
  title={Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.},
  author={Dong Dong Zhang and Bona Linke and Jing Xia Suo and Aleksandra Żivkovi{\'c} and Yannick Schreiber and Nerea Ferreir{\'o}s and Marina Henke and Gerd 7 Geisslinger and Holger Stark and Klaus Scholich},
  journal={Biological chemistry},
  year={2015},
  volume={396 6-7},
  pages={783-94}
}
FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist. FTY720 has been shown to reduce the nociceptive behavior in the paclitaxel model for chemotherapy-induced neuropathic pain through downregulation of S1P receptor 1 (S1P1) in microglia of the spinal cord. Here, we investigated the mechanisms underlying the antinociceptive effects of FTY720 in a model for trauma-induced neuropathic pain. We… CONTINUE READING