Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat.

Abstract

We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos… (More)
DOI: 10.1016/j.toxicon.2012.12.011

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