Antinociceptive effects in mice after intrathecal injection of 5'-N-ethylcarboxamide adenosine.

@article{Post1984AntinociceptiveEI,
  title={Antinociceptive effects in mice after intrathecal injection of 5'-N-ethylcarboxamide adenosine.},
  author={C. T. Post},
  journal={Neuroscience letters},
  year={1984},
  volume={51 3},
  pages={325-30}
}
When injected intrathecally in mice in a volume of 5 microliter, adenosine had no effect on tail-flick or hot-plate reaction latencies at dosages up to 1 mM concentration. There were no other behavioral effects observed either. Injecting 1 mM of the adenosine receptor agonist, 5'-N-ethylcarboxamide adenosine (NECA) caused both motor paralysis of the hind-legs with a duration of approximately 4 h and simultaneous antinociception. A slight weakness of the hindlegs, but a profound antinociceptive… CONTINUE READING

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