Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain

@article{Urtikova2012AntinociceptiveEO,
  title={Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain},
  author={Nataliya Urtikova and Nad{\`e}ge Berson and Juliette Van Steenwinckel and St{\'e}phane Doly and Marie Conrath},
  journal={PAIN},
  year={2012},
  volume={153},
  pages={1320-1331}
}
Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in dorsal root ganglia (DRG) and the sciatic nerve. We showed that 5-HT(2B) receptor activation both prevents and reduces CCI-induced allodynia. Intrathecal administration of 5-HT(2B… CONTINUE READING
2
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Efficient analysis of experimental observations

WJ Dixon
  • Annu Rev Pharmacol Toxicol
  • 1980
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Serotonin in pain and analgesia: actions in the periphery.

  • Molecular neurobiology
  • 2004
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats.

  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2010
VIEW 1 EXCERPT