Antinociceptive effect of Phyllanthus fraternus extract in complete Freund's adjuvant induced chronic pain in mice

  title={Antinociceptive effect of Phyllanthus fraternus extract in complete Freund's adjuvant induced chronic pain in mice},
  author={Atul R Chopade and Fahim J. Sayyad},
  journal={Biomedicine \& Aging Pathology},
Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice.
It is suggested that the oral or topical treatment with B. thyrsoides presents antinociceptive actions in an arthritic pain model without causing adverse effects.
Pharmacological Aspects of Phyllanthus fraternus Standardized Extract (Rich in Lignans and Tannins) as a Pain Modulator
In order to estimate, chronic pain modulating potential of P. fraternus, histopathological studies and measurement of prostaglandin E-2 (PGE2) were studied and thermal/heat hyperalgesia, mechanical hyperalgeia and muscle circumferences were determined in the current experimental model.
Protective role of Phyllanthusfraternus in alloxan-induced diabetes in rats
Molecular Docking Studies of Phytocompounds from the Phyllanthus Species as Potential Chronic Pain Modulators
The docking scores and analysis of the interactions of the phytocompounds with target proteins suggest that important molecules like lupeol, phyllanthin, hypopyllanth in, corilagin, epicatechin, and most of the other compounds have the ability to bind to multiple targets involved in inflammatory hyperalgesia.
Mechanisms involved in the antinociceptive and anti-inflammatory effects of a new triazole derivative: 5-[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole (LQFM-096)
The findings suggest antinociceptive effect of LQFM-096 and implicate the modulation of ASICs/TRPV1 channels by opioid/KATP pathway.
Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana
The results while justifying the traditional use of the plant materials in the treatment of malaria, however, suggest their cautious use.
Phytotherapeutical implications in pain perception
Mini ethonopharmacological approaches in pain conditions in the context of schizop highlighted some cases of inappropriate usage of plants in traditional therapy and seems that by replacing fully synthesized chemical products, the risk of side have curing effects on the psychotic activities in schizophrenia.
Use of medicinal plants in rheumatology
The use of medicinal plants is quite common in rheumatology in Morocco, however, the association between this practice and educational, social or economical levels of patients was not found.


Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus
Findings showed that the extracts of Phyllanthus amarus and PhyllAnthus fraternus given intraperitoneally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner.
Protective Efficacy of Phyllanthus Fraternus against Cerebral Ischemia Reperfusion in Rat
The present study reveals that Phyllanthus can be used to prevent or reduce the deterioration caused by free radicals thereby preventing subsequent pathological and biochemical changes which occur during cerebral ischemia.