Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis

@article{Silva2013AntinociceptiveEO,
  title={Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis},
  author={Anne Dayse Soares da Silva and L. H. A. Cavalcante-Silva and C. B. B. da Matta and D. F. Silva and M. V. Ara{\'u}jo and J. Tavares and M. S. da Silva and M. S. Alexandre-Moreira},
  journal={Natural Product Research},
  year={2013},
  volume={27},
  pages={1695 - 1699}
}
In this study, we investigated the antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID50 = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response… Expand
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