Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy.

@article{Kayser1999AntinociceptiveEO,
  title={Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy.},
  author={Val{\'e}rie Kayser and Dennis Baun Christensen and Gis{\'e}le Guilbaud and F. S{\'a}nchez San Rom{\'a}n},
  journal={Life sciences},
  year={1999},
  volume={66 5},
  pages={
          433-9
        }
}
Trimebutine (2-dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoate, hydrogen maleate) relieves abdominal pain in humans. In the present study, the antinociceptive action of systemic (S)-N-desmethyl trimebutine, a stereoisomer of N-monodesmethyl trimebutine, the main metabolite of trimebutine in humans, was studied in a rat model of neuropathic pain produced by chronic constriction injury to the sciatic nerve. Mechanical (vocalization threshold to hindpaw pressure) stimulus was used… CONTINUE READING
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