Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

@article{Ansonoff2006AntinociceptiveAH,
  title={Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.},
  author={Michael A. Ansonoff and Jiwen Zhang and Traci A. Czyzyk and Richard B. Rothman and Jeremy Stewart and Heng Li Xu and Jordan Zjwiony and Daniel J. Siebert and Feng Yang and Bryan L. Roth and John E. Pintar},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={318 2},
  pages={641-8}
}
Salvia divinorum is a natural occurring hallucinogen that is traditionally used by the Mazatec Indians of central Mexico. The diterpene salvinorin A was identified as an active component of S. divinorum over 20 years ago, but only recently has biochemical screening indicated that a molecular target of salvinorin A in vitro is the kappa-opioid receptor. We have examined whether salvinorin A, the C2-substituted derivative salvinorinyl-2-propionate, and salvinorin B can act as kappa-opioid… CONTINUE READING

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2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A.

The Journal of pharmacology and experimental therapeutics • 2008
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