Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models

@article{Godin2011AntinociceptiveAA,
  title={Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models},
  author={Adriana Martins Godin and Wallace Carvalho Ferreira and Leonardo Tadeu S. Rocha and Jo{\~a}o Gabriel Toledo Seniuk and Andr{\'e} Luiz L. Paiva and Leonardo A. Merlo and Elias B. Nascimento and Leandro F. S. Bastos and M{\'a}rcio de Matos Coelho},
  journal={Pharmacology Biochemistry and Behavior},
  year={2011},
  volume={99},
  pages={782-788}
}
Although there is evidence for the anti-inflammatory activity of nicotinamide, there is no evaluation of its effects in models of nociceptive and inflammatory pain. In addition, there is no information about the potential anti-inflammatory and antinociceptive activities of the nicotinamide isomers, picolinamide and isonicotinamide. Per os (p.o.) administration of nicotinamide (1000 mg/kg, -1h) inhibited the first and second phases of the nociceptive response induced by formalin in mice. In the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-4 of 4 extracted citations

Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged liver.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie • 2016
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Nicotinamide is a potent inhibitor of proinflammatory cytokines.

Clinical and experimental immunology • 2003
View 6 Excerpts
Highly Influenced

Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.

Sheng li xue bao : [Acta physiologica Sinica] • 2009
View 5 Excerpts
Highly Influenced

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

SM Westaway, ThompsonM, +3 authors DJ Mitchell
Bioorg Med Chem Lett 2008;18:5609–13 • 2008
View 4 Excerpts
Highly Influenced

Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

Biochemical and biophysical research communications • 1994
View 4 Excerpts
Highly Influenced