Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models

  title={Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models},
  author={Adriana Martins Godin and Wallace Carvalho Ferreira and Leonardo Tadeu S. Rocha and Jo{\~a}o Gabriel Toledo Seniuk and Andr{\'e} Luiz L. Paiva and Leonardo A. Merlo and Elias B. Nascimento and Leandro F. S. Bastos and M{\'a}rcio de Matos Coelho},
  journal={Pharmacology Biochemistry and Behavior},
Although there is evidence for the anti-inflammatory activity of nicotinamide, there is no evaluation of its effects in models of nociceptive and inflammatory pain. In addition, there is no information about the potential anti-inflammatory and antinociceptive activities of the nicotinamide isomers, picolinamide and isonicotinamide. Per os (p.o.) administration of nicotinamide (1000 mg/kg, -1h) inhibited the first and second phases of the nociceptive response induced by formalin in mice. In the… CONTINUE READING


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