Antinociceptive analogs of orphanin FQ/nociceptin(1-11).

  title={Antinociceptive analogs of orphanin FQ/nociceptin(1-11).},
  author={John P Mathis and I E Goldberg and Grace C. Rossi and Liza Leventhal and Gavril W Pasternak},
  journal={Life sciences},
  volume={63 11},
  pages={PL 161-6}
The presence of pairs of basic amino acids within the sequence of orphanin FQ/nociceptin (OFQ/N) peptide, the endogenous ligand for the ORL1/KOR-3 receptor, has raised the possibility that processing might generate pharmacologically important truncated peptides, including OFQ/N(1-11). OFQ/N(1-11) is pharmacologically active in vivo with a potency comparable… CONTINUE READING