Antinociceptive action of epidural K+(ATP) channel openers via interaction with morphine and an alpha(2)- adrenergic agonist in rats.

@article{Asano2000AntinociceptiveAO,
  title={Antinociceptive action of epidural K+(ATP) channel openers via interaction with morphine and an alpha(2)- adrenergic agonist in rats.},
  author={Tsutomu Asano and Shuji Dohi and Hiroki Iida},
  journal={Anesthesia and analgesia},
  year={2000},
  volume={90 5},
  pages={1146-51}
}
Potassium (K(+)) channels may play some role in the analgesic actions of mu-opioid agonists and alpha(2)-adrenergic agonists (alpha(2) agonists). We examined whether the adenosine triphosphate-sensitive K(+)(K(+)(ATP)) channel openers, levcromakalim and nicorandil, (given epidurally), might have antinociceptive effects in a tail flick test in adult male Sprague-Dawley rats implanted with a lumbar epidural catheter. The interactions with morphine and an alpha(2) agonist were also examined. The… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
These data suggest that levcromakalim and nicorandil potentiate the analgesic action of both morphine and dexmedetomidine , probably via an activation of K(+)(ATP ) channels at the spinal cord level .
Potassium ( K(+ ) ) channels may play some role in the analgesic actions of mu - opioid agonists and alpha(2)-adrenergic agonists ( alpha(2 ) agonists ) .
Potassium ( K(+ ) ) channels may play some role in the analgesic actions of mu - opioid agonists and alpha(2)-adrenergic agonists ( alpha(2 ) agonists ) .
All Topics