Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models

  title={Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models},
  author={Sahar Majdi Jaffal and Manal Ahmad Abbas},
Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. In this study, the analgesic effect of A. biebersteinii methanolic flower extract was tested in three pain models, namely: writhing, tail-flick and paw-licking (formalin) tests. A. biebersteinii extract inhibited abdominal cramps produced by acetic… 

Analgesic and Anxiolytic Activities of Achillea Biebersteinii: Evidence for the Involvement of GABAergic Systems

Achillea biebersteinii exerted analgesic, anxiolytic but no antidepressant activity and its effect involved interaction with GABAA and GABAB systems.

ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

Viphyllin could be a natural pain-relieving agent involving safer pain signaling mechanisms, unlike conventional opiates and NSAIDS, according to the findings of this study.

Analgesic Property of Loranthus Acaciae Studied by Molecular Docking and Biological Assays

It is indicated that the analgesic action of L. acaciae was mediated by interaction with opioid and adenosine receptors, and could be due to the binding of lupeol, campesterol & rhoifolin to μ-opioid receptor.

Identification of Mushroom and Murine Tyrosinase Inhibitors from Achillea biebersteinii Afan. Extract

To optimize the extraction procedure of the plant material, evaluate its phytochemical composition, and compare anti-tyrosinase potential of A. biebersteinii extracts and fractions, ferulic acid was proposed as the most active murine tyrosin enzyme inhibitor.

Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

Abstract The aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract of Achillea arabica flower extract against streptozotosine (STZ)-induced in

An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants

Medicinal herbs and their bioactive compounds exhibit antiangiogenic, antioxidant, sedative and pain-alleviating properties and the effects recorded until now encourage their use for the conservative management of endometriosis.

Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models

A. andrachne showed promising anti-nociceptive effects in thermal and chemical models of pain and can open an avenue for natural pain relief.



Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs

The hydroalcohol extracts of Achillea millefolium L. (AM) and Artemisia vulgaris L. (AV), both belonging to the Asteraceae family, were evaluated by the hot plate, writhing, formalin and intestinal

Antinociceptive and Anti-inflammatory Activities and Acute Toxicity of Achillea nobilis. subsp. neilreichii. Extract in Mice and Rats

  • N.U. Karabay-YavasogluC. KaramenderesS. BaykanŞ. Apaydın
  • Biology
  • 2007
The current results demonstrate that an ethanol extract of A. L. neilreichii exerts anti-inflammatory activity.

Characterization of the Antinociceptive Mechanisms of Khat Extract (Catha edulis) in Mice

Results provide strong evidence that the antinociceptive activity of khat extract is mediated via opioidergic, GABAergic, and dopaminergic pathways and may be linked to the different types of pain generated in animal models.


Achillea species have been used for their anti-inflammatory, analgesic, spasmolytic, hemostatic, digestive and cholagogue effects in Turkish folk medicine and showed significant antinociceptive and anti- inflammatory activity at 500 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage.

An evaluation of the anti-inflammatory, antipyretic and analgesic effects of hydroethanol leaf extract of Albizia zygia in animal models

The results suggest that AZE possesses anti-inflammatory, antipyretic and analgesic properties, which justifies its traditional use and shows the involvement of the opioidergic, adenosinergic and the muscarinic cholinergic pathways in the analgesic effects of AZE.

Toxic essential oils: anxiolytic, antinociceptive and antimicrobial properties of the yarrow Achillea umbellata Sibth. et Sm. (Asteraceae) volatiles.

Analgesic, antipyretic and antiinflammatory effects of Achillea ageratum

The phytochemical investigation of the aqueous and methanol extract of Achillea ageratum L. (Asteraceae) revealed the presence of flavonic compounds: luteolin, quercetin and 7‐O‐β‐luteolin.

Antioxidant Activity and Ethno pharmacological Survey of Achillea biebersteinii Afan. in the Treatment of Dysmenorrhoea in Traditional Medicine of Golestan Province, Iran

These finding not only confirm the use of the plant in the traditional medicine of Golestan province, but also can serve as a basis for phytochemical and pharmaceutical researches to identify and produce effective herbal drugs in prevention or treatment of common dysmenorrhoea.

Evaluation of Hypoglycemic Effect of Achillea biebersteinii Afan., Growing in Syria, in Induced Diabetic Rats

Supported by many studies and botanical surveys, the potential role of medicinal plants as antidiabetic agents has dramatically raised. The present study was designed to investigate the hypoglycemic