Antinociceptive action against colonic distension by brain orexin in conscious rats

@article{Okumura2015AntinociceptiveAA,
  title={Antinociceptive action against colonic distension by brain orexin in conscious rats},
  author={Toshikatsu Okumura and Tsukasa Nozu and Shima Kumei and Kaoru Takakusaki and Saori Miyagishi and Masumi Ohhira},
  journal={Brain Research},
  year={2015},
  volume={1598},
  pages={12-17}
}
Brain orexin improves intestinal barrier function via the vagal cholinergic pathway
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TLDR
It is proposed for the first time that orexin-A may act in the brain to stimulate gastric acid secretion by modulating the vagal system and is a candidate mediator of cephalic phase gastric secretion.
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TLDR
Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.
Central orexin-A increases gastric motility in rats
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TLDR
The results suggest that endogenous orexin-A in the brain is involved in the vagal-dependent stimulation of gastric contractions in non-fasted rats.
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TLDR
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