Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice

@article{Tallarida2003AntinociceptiveSA,
  title={Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice},
  author={Ronald J. Tallarida and Alan Cowan and Robert B Raffa},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={307},
  pages={699 - 704}
}
Glucosamine (2-amino-2-deoxy-d-glucose) and glucosamine-containing products have been reported to have efficacy in the treatment of various musculoskeletal disorders. Glucosamine's efficacy, including reduction of pain, is attributed to disease-modifying properties, specifically to cartilage-rebuilding associated with modulation of interleukin-1-induced activation of chondrocytes and to inhibition of proinflammatory effects of the nuclear factor-κB pathway. However, glucosamine has not been… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.
TLDR
A rational explanation for the coexistence of dual components to tramadol-induced antinociception appears to be related to the different, but complementary and interactive, pharmacologies of its enantiomers and might form the basis for understanding its clinical profile. Expand
Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate.
TLDR
Clinical trials of glucosamine and chondroitin showed substantial benefit in the treatment of osteoarthritis but provided insufficient information about study design and conduct to allow definitive evaluation, and further studies are needed to determine if route of administration is important and whether the therapeutic effect is site specific. Expand
Glucosamine Sulfate for Osteoarthritis
TLDR
There is evidence that glucosamine sulfate may provide pain relief, reduce tenderness, and improve mobility in patients with OA. Expand
Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol).
TLDR
It is demonstrated for the first time that acetaminophen-induced antinociception involves a "self-synergistic" interaction between spinal and supraspinal sites and, furthermore, that the self-synergy involves an endogenous opioid pathway. Expand
Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee.
TLDR
There was no significant difference in pain reduction between the glucosamine hydrochloride and placebo groups as measured by WOMAC, but the secondary endpoints of cumulative pain reduction as measures by daily diary and knee examination were favorable, suggesting that glucosamines hydrochlorides benefits some patients with knee OA. Expand
Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatment.
  • M. Gottlieb
  • Medicine
  • Journal of manipulative and physiological therapeutics
  • 1997
TLDR
The rationales for using NSAIDs in the treatment of osteoarthritis is controversial and openly contested, and their use should be discouraged and their classification as a first choice conservative treatment should be abolished. Expand
Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatment.
TLDR
The rationales for using NSAIDs in the treatment of osteoarthritis is controversial and openly contested, and their use should be discouraged and their classification as a first choice conservative treatment should be abolished. Expand
Response surface analysis of synergism between morphine and clonidine.
TLDR
Earlier studies, which found synergism for these drugs while also providing surface views of additivity and synergism that form the basis of isobolographic analysis, are confirmed. Expand
Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice.
TLDR
Support for the concept of a common analgesic receptor mechanism for morphine and nalorphine was found in experiments showing that morphine-tolerant mice were cross-tolerance to nal Morphine and that naloxone, a pure opioid antagonist, blocked the stretching inhibitory effects of morphine andnalorphines to the same extent. Expand
Statistical analysis of drug-drug and site-site interactions with isobolograms.
TLDR
A detailed statistical analysis of the isobolographic method is presented with examples of the statistical procedures, a rational basis for selecting proportions of each drug in the combination, and a relatively novel application of theIsobologram concept, i.e., interactions involving different anatomical sites. Expand
...
1
2
3
4
...