Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice

@article{Tallarida2003AntinociceptiveSA,
  title={Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice},
  author={Ronald J. Tallarida and Alan Cowan and Robert B Raffa},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={307},
  pages={699 - 704}
}
  • Ronald J. Tallarida, Alan Cowan, Robert B Raffa
  • Published 2003
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • Glucosamine (2-amino-2-deoxy-d-glucose) and glucosamine-containing products have been reported to have efficacy in the treatment of various musculoskeletal disorders. Glucosamine's efficacy, including reduction of pain, is attributed to disease-modifying properties, specifically to cartilage-rebuilding associated with modulation of interleukin-1-induced activation of chondrocytes and to inhibition of proinflammatory effects of the nuclear factor-κB pathway. However, glucosamine has not been… CONTINUE READING

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