Antinociceptive Effects of the Aqueous Extract of Brugmansia suaveolens Flowers in Mice

  title={Antinociceptive Effects of the Aqueous Extract of Brugmansia suaveolens Flowers in Mice},
  author={Alexander Garcia Parker and Gianni Goulart Peraza and Jana{\'i}na Sena and Eli Sinnott Silva and Maria C. F. Soares and Marta Regina Cezar Vaz and Eliana Badiale Furlong and Ana Luiza Muccillo-Baisch},
  journal={Biological Research For Nursing},
  pages={234 - 239}
The infusion of Brugmansia suaveolens, popularly known as trombeteira or cartucheira, has been used to treat pain in Brazil. The present study was conducted to test for its antinociceptive effects using the abdominal-writhing, formalin, tail-flick, and hot-plate tests in mice. The aqueous extract from B. suaveolens flowers administered intraperitoneally at doses of 100 and 300 mg/kg body weight significantly inhibited acetic acid-induced abdominal constrictions. An increase in hot-plate latency… 

Tables from this paper

Evaluation of the Analgesic Effect of Aqueous Extract of Brugmansia suaveolens Flower in Mice: Possible Mechanism Involved
The results suggest that the antinociceptive activity of AEBs may be related in part to benzodiazepine receptors, although peripheral mechanisms cannot be excluded.
Investigation of the anti‐inflammatory and analgesic effects from an extract of Aplysina caissara, a marine sponge
Results demonstrated that the extract of the marine sponge A. caissara possesses antinociceptive and anti‐edematogenic effects.
Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice
CFDv shows psychopharmacological effects suggestive of CNS-depressant drugs with promising antinociceptive activity that can be mediated both peripherally and at the central level, and decreases paw licking time in the first and second phases of the formalin test.
In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb
The extract exhibited significant analgesic effect and in vitro thrombolytic model used to check the clot lysis potential of the extract showed the presence of alkaloid, carbohydrate, flavonoids, steroid, phlobatanin and saponin.
Isolation, Structure Elucidation and Biological Investigation of Active Compounds in Cordia americana and Brugmansia suaveolens
This dissertation increases the phytochemical and pharmacological knowledge about Cordia americana and Brugmansia suaveolens, which support their use in traditional medicine.
Brugmansia suaveolens Leaf Productivity and Alkaloid Contents Under Different Doses of Organic Fertilizer
The treatment at the maximum level tested in this work (60 ton/ha) should be preferred over the other treatments, and B. suaveolens could be a potential source of tropane alkaloids for the community of Botucatu city, which is a leading city in Brazil for the cultivation of food products under organic, biodynamic, and agroecology premises.
Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice
It is suggested that liposome-encapsulated diclofenac exhibits higher antinociceptive efficacy in a dose-dependent manner in comparison with free-form dic LFO, while the lowest effect was shown with 0 mg/kgliposome formulation of 8.89%.
Phytochemical Screening and Adsorption Studies of Brugmansia Suaveolens
The present study has been designed to investigate the secondary metabolites present in the ethanol extract of Brugmansia suaveolens (BS). Furthermore the adsorptive behaviour of Brugmansia


Investigation into atropine‐induced antinociception
1 The effect of atropine on the nociceptive system was examined in mice and rats by use of the hot‐plate, writhing and tail‐flick tests. 2 Atropine dose‐dependently produced analgesia, no effect and
Antinociceptive effect of R-(+)-hyoscyamine on the conjunctival reflex test in rabbits.
The present results confirm the ability of R-(+)-hyoscyamine to produce a paradoxical antinociceptive effect mediated by a cholinergic mechanism not only in rodents but also in the rabbit.
Cholinergic-opioidergic interaction in the central amygdala induces antinociception in the guinea pig.
It is suggested that cholinergic transmission may activate the release of endorphins/enkephalins from interneurons of the CEA, resulting in antinociception.
Modified formalin test: characteristic biphasic pain response
Narcotic-antagonist analgesics: interactions with cholinergic systems.
A high correlation has been found between the activity of these compounds in this test procedure and their potency as analgesics in man and the hypothesis that cholinergic systems may be involved in the analgesic action of these drugs.
The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.
Investigation of the effect of a number of agents which alter central neurohumeral tone on the activity of morphine and the narcotic antagonists in the tail-flick and the phenylquinone tests indicates a possible involvement of central serotonergic mechanisms.
The abdominal constriction response and its suppression by analgesic drugs in the mouse.
An examination of the ability of a number of substances, including some occurring in tissues and causing pain in man, to elicit abdominal constriction responses in mice and new forms of abdomen constriction test in the mouse are described.