Antinociceptive Effect of some Amaryllidaceae Plants in Mice

  title={Antinociceptive Effect of some Amaryllidaceae Plants in Mice},
  author={Iclal Çakıcı and HEDIYE Y. Ulug and Sibel İnci and Bahar Tunctan and Nurettin Abacioglu and Ilker Kanzik and Bilge Şener},
  journal={Journal of Pharmacy and Pharmacology},
The antinociceptive effects of ethanolic extracts of Pancratium maritimum L., Narcissus tazetta subspecies tazetta and Leucojum aestivum L. bulbs have been investigated in mice using the p‐benzoquinone‐induced abdominal constriction and hot‐plate tests. 

Antinociceptive Activity of Various Extracts of Peganum harmala L. and Possible Mechanism of Action

It is demonstrated that the different extracts of Peganum harmala had both central and peripheral antinociceptive activities that may be mediated by opioid receptors.

Nepetalactone: A New Opioid Analgesic from Nepeta caesarea Boiss

The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nuda, and N. caesarea Boiss. have been screened by use of the tail‐flick and tail immersion (52.5°C)

Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae

6‐Hydroxyhaemanthamine, haemanthamines and lycorine were found to be the most potent alkaloids against P. falciparum (T9.96) and galanthamine and tazettine had the least potent activity (K1).

Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System

The results of the present study suggest that aqueous extract of Origanum vulgare L. ssp.

Plants with central analgesic activity.

The present communication constitutes a global review on plant analgesic activity with special emphasis on those found in different parts of the world, including Brazil, which act on the central

Nepetalactone : A New Opioid Analgesic from Nepeta caesarea Boiss

It is concluded that 4aa,7a,7aa-nepetalactone is the main component of the essential oil of N. caesurea, and is present at very high levels (92-95%), and has a specific opioid receptor subtype agonistic activity.

Phytochemical and Biological Investigation of Narcissus pseudonarcissus Cultivated in Egypt

The first phytochemical and biological investigation to be carried out on the Amaryllidaceae plant N. pseudonarcissus grown in Egypt resulted in the isolation of the alkaloid; 9-O-demethyl-7- O-methyllycorenine (5), reported here for the first time from family AmaryLLidaceae.

Gout Remedies in Traditional Iranian Medicine (TIM)

Five of most important references of TIM form the 9th to the 18th century were investigated for gout remedies and a special focus should be put on drugs as well as the therapeutic method targeting the gout treatment.



The pharmacology of galanthamine and its analogues.

  • A. Harvey
  • Biology, Chemistry
    Pharmacology & therapeutics
  • 1995

New Crinine-Type Alkaloids From Pancratium. Maritimum L. Growing In Turkey

Pancratium maritimum L. of Turkish origin has yielded two new crinine-type alkaloids, (-)-3β, 11α-dihroxy-1,2-dehydrocrinane and (-)-8-Hydroxy-9-methoxycrinine, determined by spectroscopic studies.

Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.

Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources of

Cytotoxic activity of Amaryllidaceae alkaloids.

Almost all of the tested alkaloids showed cytotoxic activity against fibroblastic LMTK cells, and mesembrenone showed some specificity against Molt4 cells in comparison to LMTk cells, while lycorenine was found to be the most cytot toxic compound against HepG2 hepatoma.

The effects of aggregation, electric shock, and adrenergic blocking drugs on inhibition of the "writhing syndrome".

Benzoquinone-induced writhing can be inhibited by analgesic (meperidine) and nonanalgesic drugs (amphetamine, carbinoxamine) in both isolated and aggregated mice. There was significantly more

Recent results in the search for bioactive compounds from Turkish medicinal plants

The structures of new bioactive compounds will be reviewed and data will be presented on the above aspects with crude extracts, fractions as well as pure com- pounds.

Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.

This represents a rare demonstration of chemotherapeutic efficacy (by a substance other than an interferon inducer) in a Japanese-encephalitis-virus-infected mouse model.

Screening Methods in Pharmacology

  • C. N. Gillis
  • Geology
    The Yale Journal of Biology and Medicine
  • 1965