Antinociceptive Effect of some Amaryllidaceae Plants in Mice

  title={Antinociceptive Effect of some Amaryllidaceae Plants in Mice},
  author={Iclal Çakıcı and H Y Ulug and Şule Inci and Bahar Tunctan and Nurettin Abacioglu and Ilker Kanzik and Bilge Şener},
  journal={Journal of Pharmacy and Pharmacology},
The antinociceptive effects of ethanolic extracts of Pancratium maritimum L., Narcissus tazetta subspecies tazetta and Leucojum aestivum L. bulbs have been investigated in mice using the p‐benzoquinone‐induced abdominal constriction and hot‐plate tests. 
Antinociceptive Activity of Various Extracts of Peganum harmala L. and Possible Mechanism of Action
The seeds of Peganum harmala L. (Pgh) (Zygophyllaceae) have been used in Moroccan traditional medicine to treat various diseases. The objective of this study was to investigate the analgesic effectExpand
Nepetalactone: A New Opioid Analgesic from Nepeta caesarea Boiss
The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nuda, and N. caesarea Boiss. have been screened by use of the tail‐flick and tail immersion (52.5°C)Expand
Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved.
The alkaloid extract of Peganum harmala seems to have both central and peripheral antinociceptive activities which may be mediated by opioid receptors. Expand
Evaluation of the analgesic effect of Echium amoenum Fisch & C.A. Mey. extract in mice: possible mechanism involved.
The results suggested that Echium amoenum extract has a suitable analgesic effect and further studies are required to evaluate these effects and the potential of the plant. Expand
Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae
6‐Hydroxyhaemanthamine, haemanthamines and lycorine were found to be the most potent alkaloids against P. falciparum (T9.96) and galanthamine and tazettine had the least potent activity (K1). Expand
Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System
The results of the present study suggest that aqueous extract of Origanum vulgare L. ssp. Expand
Plants with central analgesic activity.
The present communication constitutes a global review on plant analgesic activity with special emphasis on those found in different parts of the world, including Brazil, which act on the centralExpand
Nepetalactone : A New Opioid Analgesic from Nepeta caesarea Boiss
The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nuda, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5"C)Expand
Phytochemical and Biological Investigation of Narcissus pseudonarcissus Cultivated in Egypt
The first phytochemical and biological investigation to be carried out on the Amaryllidaceae plant N. pseudonarcissus grown in Egypt resulted in the isolation of the alkaloid; 9-O-demethyl-7- O-methyllycorenine (5), reported here for the first time from family AmaryLLidaceae. Expand
Gout Remedies in Traditional Iranian Medicine (TIM)
Five of most important references of TIM form the 9th to the 18th century were investigated for gout remedies and a special focus should be put on drugs as well as the therapeutic method targeting the gout treatment. Expand


The pharmacology of galanthamine and its analogues.
  • A. Harvey
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1995
Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants and is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Expand
New Crinine-Type Alkaloids From Pancratium. Maritimum L. Growing In Turkey
Pancratium maritimum L. of Turkish origin has yielded two new crinine-type alkaloids, (-)-3β, 11α-dihroxy-1,2-dehydrocrinane and (-)-8-Hydroxy-9-methoxycrinine, determined by spectroscopic studies. Expand
Recent results in the search for bioactive compounds from Turkish medicinal plants
During the p ast few years, some of the s elected Turkish medicinal plant extracts have been screened for their antibacte- rial, antifungal, antiinflammatory , analgesic, anti-platelet andExpand
Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.
Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources ofExpand
Cytotoxic activity of Amaryllidaceae alkaloids.
Almost all of the tested alkaloids showed cytotoxic activity against fibroblastic LMTK cells, and mesembrenone showed some specificity against Molt4 cells in comparison to LMTk cells, while lycorenine was found to be the most cytot toxic compound against HepG2 hepatoma. Expand
The effects of aggregation, electric shock, and adrenergic blocking drugs on inhibition of the "writhing syndrome".
Benzoquinone-induced writhing can be inhibited by analgesic (meperidine) and nonanalgesic drugs (amphetamine, carbinoxamine) in both isolated and aggregated mice. There was significantly moreExpand
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
This represents a rare demonstration of chemotherapeutic efficacy (by a substance other than an interferon inducer) in a Japanese-encephalitis-virus-infected mouse model. Expand
Screening Methods in Pharmacology
  • C. N. Gillis
  • Medicine
  • The Yale Journal of Biology and Medicine
  • 1965
Comment was incisive and much remains cogent on the neurochemical subtleties and the justification of the duplicate publication usually involved in printing symposia proceedings. Expand