Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action.

@article{Mogilski2015AntinociceptiveAA,
  title={Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action.},
  author={Szczepan Mogilski and Monika Kubacka and Aleksandra Redzicka and Grzegorz Kazek and Magdalena B Dudek and Wiesław Malinka and Barbara Filipek},
  journal={Pharmacology, biochemistry, and behavior},
  year={2015},
  volume={133},
  pages={99-110}
}
The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of the mechanisms involved in the pharmacological activity of these compounds. In the previous studies it was shown that these compounds were highly active in the phenylbenzoquinone-induced 'writhing syndrome' test and had much lower activity in the hot plate, which indicates that mainly peripheral… CONTINUE READING