Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition.

@article{Baggio2012AntinociceptionO,
  title={Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition.},
  author={Cristiane Hatsuko Baggio and Cristina Setim Freitas and Rodrigo Marcon and Maria Fernanda de Paula Werner and Giles Alexander Rae and Fhernanda Ribeiro Smiderle and Guilherme Lanzi Sassaki and Marcello Iacomini and Maria Consuelo Andrade Marques and Adair Roberto Soares dos Santos},
  journal={International journal of biological macromolecules},
  year={2012},
  volume={50 3},
  pages={872-7}
}
β-D-Glucan, a polysaccharide isolated from an edible mushroom Pleurotus pulmonarius (Fr.) Quel., presented antinociceptive activity in mice. This study evaluated the involvement of transient receptor potential (TRP) channels and protein kinase C (PKC) on antinociceptive effect of a (1→3),(1→6)-linked β-D-glucan (GL) in mice. Intraperitoneal administration of GL potently inhibited nociceptive responses induced by intraplantar injections of capsaicin, cinnamaldehyde, menthol, acidified saline and… CONTINUE READING
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