Antinociception induced by chronic exposure of rats to cigarette smoke.

@article{Anderson2004AntinociceptionIB,
  title={Antinociception induced by chronic exposure of rats to cigarette smoke.},
  author={Kenton L Anderson and Kent E. Pinkerton and Dale L Uyeminami and Christopher T. Simons and Mirela Iodi Carstens and Earl E. Carstens},
  journal={Neuroscience letters},
  year={2004},
  volume={366 1},
  pages={86-91}
}
To investigate if chronic exposure to cigarette smoke induces analgesia, rats were exposed to concentrated cigarette smoke in an environmental chamber over four successive 5-day blocks (6 h/day), with 2 smoke-free days between blocks. A control group was exposed to room air. Tail flick latencies increased significantly (analgesia) during each smoke exposure block, with a relative decline in analgesia across blocks (tolerance) and a return to control levels during the first three smoke-free… CONTINUE READING

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