Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat

@article{Poon1998AntinociceptionBA,
  title={Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat},
  author={Anthony Poon and Jana Sawynok},
  journal={Pain},
  year={1998},
  volume={74},
  pages={235-245}
}
The Antinociceptive Potencies and Interactions of Endogenous Ligands During Continuous Intrathecal Administration: Adenosine, Agmatine, and Endomorphin-1
TLDR
The results revealed that adenosine and agmatine have a small antinociceptive efficacy during continuous intrathecal administration but that both potentiate the effect of endomorphin-1, suggesting that the combination of these endogenous ligands might represent novel targets for the therapeutic modulation of pain.
Antinociception of Intrathecal Adenosine Receptor Subtype Agonists in Rat Formalin Test
TLDR
It is suggested that spinal adenosine A1 and A2A receptors may be involved in the modulation of the early and the late phase responses of the formalin test, whereas adenosines A3 receptor may beinvolved in the regulation of theLate phase response.
Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats.
TLDR
Clinical examination of intrathecal adenosine alone and with clonidine in the treatment of chronic pain states that include a component of mechanical hypersensitivity are supported and suggest that, after nerve injury,adenosine acts to reduce hypersensitivity through spinal norepinephrine release.
Allosteric Adenosine Modulation to Reduce Allodynia
TLDR
These results add to previous studies that suggest ongoing spinal release of adenosine, which is antiallodynic, in this animal model of neuropathic pain, and confirm the feasibility of the use of such modulators in the treatment of chronic pain associated with hyperalgesia and allodynia.
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TLDR
It is hypothesize that the antiallodynic effects are mediated through the activation of spinal A1 adenosine receptors and motor dysfunction effects aremediated through A2 adenosines receptors.
Classification of adenosine receptors mediating antinociception in the rat spinal cord
TLDR
The results suggest that activation of A1‐receptors in the spinal cord can produce antinociception, and that Activation of A2‐receptorors may produce an additional effect, but the relative activity of CHA in this component of activity is unusual.
Involvement of A2 adenosine receptors in spinal mechanisms of antinociception.
Effects of Intrathecal Injection of the Adenosine Receptor Agonists R‐Phenylisopropyl‐Adenosine and N‐Ethylcarboxamide‐Adenosine on Nociception and Motor Function in the Rat
TLDR
The results suggest that the receptor selectivity of R-phenylisopropyl-adenosine is diminished at higher doses and that the motor impairment is an A2-receptor-mediated effect.
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
TLDR
The results suggest that accumulation of endogenousAdenosine may contribute to seizure suppression, and that adenosine kinase and adenosinesine transport may play a pivotal role in the regulation of extracellular levels of adenoine in the central nervous system.
Role of Spinal Adenosine Receptors in Modulating the Hyperesthesia Produced by Spinal Glycine Receptor Antagonism
TLDR
The characteristics of the strychnine hyperesthesia appear to mimic the clinical phenomenon observed in patients suffering from sensory dysesthesia following nerve injury and suggest a possible role for the adenosine receptor in certain pain states.
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