Antinociception and cardiovascular responses produced by intravenous morphine: the role of vagal afferents

@article{Randich1991AntinociceptionAC,
  title={Antinociception and cardiovascular responses produced by intravenous morphine: the role of vagal afferents},
  author={Alan Randich and Cindy L. Thurston and Peter Stephan Ludwig and Michelle Timmerman and Gerald F. Gebhart},
  journal={Brain Research},
  year={1991},
  volume={543},
  pages={256-270}
}
The mechanisms of the antinociceptive, depressor and bradycardic responses produced by intravenous (i.v.) administration of morphine were examined in rats lightly anesthetized with pentobarbital sodium. Intravenous administration of 0.1, 0.25, 0.5, 1.0 or 2.5 mg/kg of morphine produced dose-dependent inhibition of the nociceptive tail flick (TF) reflex, hypotension, and bradycardia. Bilateral cervical vagotomy (CVAG) significantly attenuated the antinociception produced by i.v. morphine and the… CONTINUE READING
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