Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

@article{Millet2013AntineutrophilCA,
  title={Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?},
  author={Arnaud Millet and Magali Pederzoli-Ribeil and Lo{\"i}c Guillevin and V{\'e}ronique Witko-Sarsat and Luc Mouthon},
  journal={Annals of the Rheumatic Diseases},
  year={2013},
  volume={72},
  pages={1273 - 1279}
}
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. At least two of the diseases are believed to exhibit a common ground of pathophysiological mechanisms. These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). ANCA directed against proteinase 3 (PR3) are… Expand
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References

SHOWING 1-10 OF 103 REFERENCES
Genetically distinct subsets within ANCA-associated vasculitis.
TLDR
This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyang iitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature ofproteinase 3 ANCA -associated vasulitis. Expand
ANCA-associated vasculitides—advances in pathogenesis and treatment
TLDR
Evidence from clinical studies, and both in vitro and in vivo experiments, supports a pathogenic role for ANCAs in the development of AAV; evidence is stronger for myeloperoxidase- ANCAs than for proteinase-3-ANCAs. Expand
New pathophysiological insights and treatment of ANCA-associated vasculitis.
TLDR
Novel pathophysiological findings in AAV are highlighted and put into context with the current understanding of disease mechanisms and implications for present and new therapeutic strategies are discussed. Expand
Prevalence and spectrum of rheumatic diseases associated with proteinase 3-antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA.
TLDR
A divergence in the disease spectrum between PR3- and MPO-ANCA-positive patients is found, characterized by higher DEI and extrarenal manifestations in the PR3 -ANCA group. Expand
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
TLDR
Although there is considerable overlap, the anti-PR3- and anti-MPO-associated vasculitides are each characterized by particular clinical and histopathological findings. Expand
Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome.
TLDR
The prevalence and antigen specificity of ANCAs in a large cohort of patients with Churg-Strauss syndrome was examined and the relationship between ANCA positivity and clinicopathologic features was evaluated. Expand
Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.
TLDR
ANCA specificity independently predicts relapse among patients with AAV with renal disease, and classification and diagnostic systems that incorporate ANCA specificity provide a more useful tool than the clinical pathologic category alone for predicting relapse. Expand
Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis
TLDR
This analysis suggests that AAV encompasses five classes associated with different outcomes, and as compared with the traditional GPA–MPA separation, this classification system may better reflect the phenotypic spectrum of AAV. Expand
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
TLDR
This in vivo study provides the first evidence for a pathogenic effect of proteinase 3-specific ANCAs at local sites of inflammation. Expand
Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.
TLDR
This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis as well as the pathogenic potential of antibodies alone. Expand
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