Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?
@article{Millet2013AntineutrophilCA, title={Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?}, author={Arnaud Millet and Magali Pederzoli-Ribeil and Lo{\"i}c Guillevin and V{\'e}ronique Witko-Sarsat and Luc Mouthon}, journal={Annals of the Rheumatic Diseases}, year={2013}, volume={72}, pages={1273 - 1279} }
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. At least two of the diseases are believed to exhibit a common ground of pathophysiological mechanisms. These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). ANCA directed against proteinase 3 (PR3) are…
128 Citations
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References
SHOWING 1-10 OF 103 REFERENCES
Genetically distinct subsets within ANCA-associated vasculitis.
- Medicine, BiologyThe New England journal of medicine
- 2012
This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyang iitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature ofproteinase 3 ANCA -associated vasulitis.
New pathophysiological insights and treatment of ANCA-associated vasculitis.
- Biology, MedicineKidney international
- 2011
Novel pathophysiological findings in AAV are highlighted and put into context with the current understanding of disease mechanisms and implications for present and new therapeutic strategies are discussed.
Prevalence and spectrum of rheumatic diseases associated with proteinase 3-antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA.
- Medicine, BiologyRheumatology
- 2001
A divergence in the disease spectrum between PR3- and MPO-ANCA-positive patients is found, characterized by higher DEI and extrarenal manifestations in the PR3 -ANCA group.
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
- Medicine, BiologyKidney international
- 2000
Although there is considerable overlap, the anti-PR3- and anti-MPO-associated vasculitides are each characterized by particular clinical and histopathological findings.
Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome.
- Medicine, BiologyArthritis and rheumatism
- 2005
The prevalence and antigen specificity of ANCAs in a large cohort of patients with Churg-Strauss syndrome was examined and the relationship between ANCA positivity and clinicopathologic features was evaluated.
Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.
- Medicine, BiologyArthritis and rheumatism
- 2012
ANCA specificity independently predicts relapse among patients with AAV with renal disease, and classification and diagnostic systems that incorporate ANCA specificity provide a more useful tool than the clinical pathologic category alone for predicting relapse.
Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis
- MedicineAnnals of the rheumatic diseases
- 2013
This analysis suggests that AAV encompasses five classes associated with different outcomes, and as compared with the traditional GPA–MPA separation, this classification system may better reflect the phenotypic spectrum of AAV.
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
- Biology, MedicineBlood
- 2004
This in vivo study provides the first evidence for a pathogenic effect of proteinase 3-specific ANCAs at local sites of inflammation.
Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.
- Medicine, BiologyThe Journal of clinical investigation
- 2002
This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis as well as the pathogenic potential of antibodies alone.
Antimyeloperoxidase antibodies are a useful marker of disease activity in antineutrophil cytoplasmic antibody-associated vasculitides
- Medicine, BiologyAnnals of the rheumatic diseases
- 2009
Through monitoring, antimyeloperoxidase antibodies are a useful marker of disease activity and a good predictor of relapse in antimYeloperxidase-associated vasculitides.