Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

@article{Millet2013AntineutrophilCA,
  title={Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?},
  author={Arnaud Millet and Magali Pederzoli-Ribeil and Lo{\"i}c Guillevin and V{\'e}ronique Witko-Sarsat and Luc Mouthon},
  journal={Annals of the Rheumatic Diseases},
  year={2013},
  volume={72},
  pages={1273 - 1279}
}
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. At least two of the diseases are believed to exhibit a common ground of pathophysiological mechanisms. These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). ANCA directed against proteinase 3 (PR3) are… Expand
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Immunopathogenesis of ANCA-Associated Vasculitis
TLDR
The current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers are summarized and it is illustrated how the extending knowledge of the Immunopathogenesis will likely translate into development of a personalized medicine approach in the management of AN CA-associated Vasculitis. Expand
ANCA-associated vasculitis — clinical utility of using ANCA specificity to classify patients
TLDR
Accumulating evidence suggests that ANCA specificity could be better than clinical diagnosis for defining homogeneous groups of patients, as PR3-ANCA and MPO-AnCA are associated with different genetic backgrounds and epidemiology. Expand
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review
TLDR
Initial vasculitis activity, prognostic factor score, age and specific organ-involvement have been found to be associated with either all-cause mortality or poor disease course in AAV patients. Expand
Antineutrophilic cytoplasmic antibody-associated vasculitis and malignant hemopathies, a retrospective study of 16 cases.
TLDR
The association of ANCA-associated vasculitis and malignant hemopathy is rare but must nevertheless be recognized because: (i) the clinical signs of both pathologies are not specific, (ii) the survival scores that are used for AN CA-associated Vasculitis do not appear to be applicable, and (iii) both pathsologies must be taken into account in order to implement an effective therapeutic strategy that limits the inherent risks. Expand
Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.
TLDR
This review synthesizes knowledge of the pathogenesis of EGPA and attempts to distinguish EGPA from other diseases including other AAVs, asthma, allergy and hypereosinophilic-associated conditions and speculate about the preponderant mechanisms, which could explain the two disease phenotypes. Expand
Antineutrophil cytoplasmic antibody positivity in IgG4-related disease: A case report and review of the literature
Background: IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by serum IgG4 elevation and tissue infiltration of IgG4-positive plasma cells. Substantial overlap between… Expand
Clinical analysis of patients with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
TLDR
Analysis of clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis in 132 patients in China found that MPO- ANCA may play a pathogenic role in the associated vasculopathy, and the diverse clinical manifestations might be related with the different characteristics of MPO. Expand
Clinical analysis of patients with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
TLDR
Analysis of the clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis in 132 patients in China found that MPO- ANCA may play a pathogenic role in the associated Vasculitis, and the diverse clinical manifestations might be related with the different characteristics of MPO -ANCA. Expand
Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis with a unique imaging presentation of organizing pneumonia: A case report
TLDR
The possibility of AAV should be considered by ordering patients’ serum ANCA and occult hematuria tests when diagnosing OP, because of only a few reported cases with organizing pneumonia (OP). Expand
Systematic Histological Scoring Reveals More Prominent Interstitial Inflammation in Myeloperoxidase-ANCA Compared to Proteinase 3-ANCA Glomerulonephritis
TLDR
MPO-ANCA GN is associated with more severe deterioration of kidney function independent of systemic markers of AAV disease activity, and is also associated with increased proteinuria in MPO- ANCA GN and a decreased fraction of normal glomeruli. Expand
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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