Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

@article{Millet2013AntineutrophilCA,
  title={Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?},
  author={Arnaud Millet and Magali Pederzoli-Ribeil and Lo{\"i}c Guillevin and V{\'e}ronique Witko-Sarsat and Luc Mouthon},
  journal={Annals of the Rheumatic Diseases},
  year={2013},
  volume={72},
  pages={1273 - 1279}
}
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. At least two of the diseases are believed to exhibit a common ground of pathophysiological mechanisms. These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). ANCA directed against proteinase 3 (PR3) are… 
Immunopathogenesis of ANCA-Associated Vasculitis
TLDR
The current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers are summarized and it is illustrated how the extending knowledge of the Immunopathogenesis will likely translate into development of a personalized medicine approach in the management of AN CA-associated Vasculitis.
ANCA-associated vasculitis — clinical utility of using ANCA specificity to classify patients
TLDR
Accumulating evidence suggests that ANCA specificity could be better than clinical diagnosis for defining homogeneous groups of patients, as PR3-ANCA and MPO-AnCA are associated with different genetic backgrounds and epidemiology.
Antineutrophil cytoplasmic antibody positivity in IgG4-related disease: A case report and review of the literature
TLDR
It is demonstrated that ANCA positivity in patients with biopsy-proven IgG4-RD should prompt the exclusion of a concomitant vasculitic process; a positive ANCA does not exclude the diagnosis of IgG3-RD; con fi rmation through immunoenzymatic assays of the ANCA specifi city, clinical-pathological correlation, and histopathological evaluation remain crucial steps for the differential diagnosis.
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review
TLDR
Initial vasculitis activity, prognostic factor score, age and specific organ-involvement have been found to be associated with either all-cause mortality or poor disease course in AAV patients.
Clinical analysis of patients with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
TLDR
Analysis of clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis in 132 patients in China found that MPO- ANCA may play a pathogenic role in the associated vasculopathy, and the diverse clinical manifestations might be related with the different characteristics of MPO.
Clinical analysis of patients with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
TLDR
Analysis of the clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis in 132 patients in China found that MPO- ANCA may play a pathogenic role in the associated Vasculitis, and the diverse clinical manifestations might be related with the different characteristics of MPO -ANCA.
Systematic Histological Scoring Reveals More Prominent Interstitial Inflammation in Myeloperoxidase-ANCA Compared to Proteinase 3-ANCA Glomerulonephritis
TLDR
MPO-ANCA GN is associated with more severe deterioration of kidney function independent of systemic markers of AAV disease activity, and is also associated with increased proteinuria in MPO- ANCA GN and a decreased fraction of normal glomeruli.
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References

SHOWING 1-10 OF 103 REFERENCES
Genetically distinct subsets within ANCA-associated vasculitis.
TLDR
This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyang iitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature ofproteinase 3 ANCA -associated vasulitis.
New pathophysiological insights and treatment of ANCA-associated vasculitis.
TLDR
Novel pathophysiological findings in AAV are highlighted and put into context with the current understanding of disease mechanisms and implications for present and new therapeutic strategies are discussed.
Prevalence and spectrum of rheumatic diseases associated with proteinase 3-antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA.
TLDR
A divergence in the disease spectrum between PR3- and MPO-ANCA-positive patients is found, characterized by higher DEI and extrarenal manifestations in the PR3 -ANCA group.
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
TLDR
Although there is considerable overlap, the anti-PR3- and anti-MPO-associated vasculitides are each characterized by particular clinical and histopathological findings.
Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome.
TLDR
The prevalence and antigen specificity of ANCAs in a large cohort of patients with Churg-Strauss syndrome was examined and the relationship between ANCA positivity and clinicopathologic features was evaluated.
Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.
TLDR
ANCA specificity independently predicts relapse among patients with AAV with renal disease, and classification and diagnostic systems that incorporate ANCA specificity provide a more useful tool than the clinical pathologic category alone for predicting relapse.
Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis
TLDR
This analysis suggests that AAV encompasses five classes associated with different outcomes, and as compared with the traditional GPA–MPA separation, this classification system may better reflect the phenotypic spectrum of AAV.
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
TLDR
This in vivo study provides the first evidence for a pathogenic effect of proteinase 3-specific ANCAs at local sites of inflammation.
Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.
TLDR
This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis as well as the pathogenic potential of antibodies alone.
Antimyeloperoxidase antibodies are a useful marker of disease activity in antineutrophil cytoplasmic antibody-associated vasculitides
TLDR
Through monitoring, antimyeloperoxidase antibodies are a useful marker of disease activity and a good predictor of relapse in antimYeloperxidase-associated vasculitides.
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