Antineuronal antibodies in sporadic late-onset cerebellar ataxia

  title={Antineuronal antibodies in sporadic late-onset cerebellar ataxia},
  author={Katrin Buerk and Manfred T. Wick and G. Roth and Patrice Decker and Raymond Voltz},
  journal={Journal of Neurology},
Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the… CONTINUE READING

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