Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies.

@article{Calviello2009AntineoplasticEO,
  title={Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies.},
  author={Gabriella Calviello and Simona Serini and Elisabetta Piccioni and Gloria Pessina},
  journal={Nutrition and cancer},
  year={2009},
  volume={61 3},
  pages={287-301}
}
Many data support the beneficial effect of n-3 polyunsaturated fatty acids (PUFAs) as chemopreventive and chemotherapeutic agents in the treatment of several chronic pathologies including cancer. Different molecular mechanisms have been proposed to explain their effects, including alterations in arachidonic acid oxidative metabolism and metabolic conversion of n-3 PUFAs to novel discovered bioactive derivatives; modification of oxidative stress; changes in cell membrane fluidity and structure… CONTINUE READING
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