Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea.

@article{Pettit2006AntineoplasticA5,
  title={Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea.},
  author={George R. Pettit and Atsushi Numata and Chika Iwamoto and Yoshihide Usami and Takeshi Yamada and Hirofumi Ohishi and Gordon M. Cragg},
  journal={Journal of natural products},
  year={2006},
  volume={69 3},
  pages={323-7}
}
Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of… CONTINUE READING

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