Antineoplastic activity of poly(L-lysine) with some ascites tumor cells.

@article{Arnold1979AntineoplasticAO,
  title={Antineoplastic activity of poly(L-lysine) with some ascites tumor cells.},
  author={L. J. Arnold and A. Dagan and J. Gutheil and N. Kaplan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 7},
  pages={
          3246-50
        }
}
  • L. J. Arnold, A. Dagan, +1 author N. Kaplan
  • Published 1979
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly a 100% remission from subsequent tumor growth. Rechallenge of "cured" animals with tumor cells, however shows no long-term immunological protection. In tissue culture, poly(L… Expand
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