Antineoplastic Activity of Highly Purified Bacterial Glutaminases

@article{Roberts1970AntineoplasticAO,
  title={Antineoplastic Activity of Highly Purified Bacterial Glutaminases},
  author={Joseph Roberts and John S. Holcenberg and William C. Dolowy},
  journal={Nature},
  year={1970},
  volume={227},
  pages={1136-1137}
}
SEVERAL lines of evidence motivated the treatment of neoplasms by glutaminase to cause glutamine deprivation. Certain tumour cells grown in tissue culture require glutamine at a level which is tenfold or greater than that of any other amino-acid1,2. Glutamine participates in a wide variety of metabolic reactions in mammalian cells3. It has been suggested that one of the important functions of glutamine in the metabolism of certain tumours may be as a direct precursor of glutamic acid, which can… 

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