Antineoplastic Activity of Highly Purified Bacterial Glutaminases

  title={Antineoplastic Activity of Highly Purified Bacterial Glutaminases},
  author={Joseph Roberts and John S. Holcenberg and W C Dolowy},
SEVERAL lines of evidence motivated the treatment of neoplasms by glutaminase to cause glutamine deprivation. Certain tumour cells grown in tissue culture require glutamine at a level which is tenfold or greater than that of any other amino-acid1,2. Glutamine participates in a wide variety of metabolic reactions in mammalian cells3. It has been suggested that one of the important functions of glutamine in the metabolism of certain tumours may be as a direct precursor of glutamic acid, which can… CONTINUE READING
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