Antimycotic activity of Melaleuca alternifolia essential oil and its major components

  title={Antimycotic activity of Melaleuca alternifolia essential oil and its major components},
  author={Brunello Oliva and E. M. Piccirilli and T. Ceddia and Eugenio Pontieri and Paolo Aureli and Anna Maria Ferrini},
  journal={Letters in Applied Microbiology},
Aims: The aim of this study was to analyse the antimycotic properties of Melaleuca alternifolia essential oil (tea tree oil, TTO) and its principal components and to compare them with the activity of 5‐fluorocytosine and amphotericin B. 

In vitro antifungal activity of the tea tree (Melaleuca alternifolia) essential oil and its major components against plant pathogens

Aims:  The aim of this study was to examine the effect of Melaleuca alternifolia essential oil (TTO) and its principal components on four cereal‐pathogenic fungi.

Antifungal activity of essential oils against filamentous fungi determined by broth microdilution and vapour contact methods

Aims:  The in vitro activity of some essential oils (EO) (thyme red, fennel, clove, pine, sage, lemon balm and lavender) against clinical and environmental fungal strains was determined.

Chemistry and Biological Activities of Essential Oils from Melaleuca L. Species

Important essential oil-producing species and two subspecies of Melaleuca in terms of their essential oil chemical composition, medicinal applications, and leaf morphoanatomy are described.

Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

This review summarizes recent developments in understanding of the antimicrobial and anti-inflammatory activities of the tea tree oil and its components, as well as clinical efficacy.

Effect of Melaleuca Alternifolia and Its Components on Candida Albicans and Candida Tropicalis

The essential oil of Melaleuca alternifolia is an herbal antifungal action and preventive scale pharmaceutical or cosmetic. The aim of this study was to evaluate the efficacy of Melaleuca

Preventive Potential and Action Mechanism of Essential Oils Against Dermatophytes

This chapter compares the antidermatophytic action of common synthetic antifungals and different herbals useful for prevention of dominant dermatophytes, besides giving information on the preventive potential and mechanism of action of different essential oils vis-a-vis some synthetic antIfungals.

In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species

The data suggest that terpinen-4-ol is a likely mediator of the in vitro and in vivo activity of TTO, and holds promise for the treatment of vaginal candidiasis, and particularly the azole-resistant forms.


The in v itro anti fungal activity of tea tree oil (TTO), the essential oil of Melaleuca alternifolia, has been evaluated against the mycotoxin producer Aspergillus paras it icus. The minimum

Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives

A diffusion test for the requirement for the degree of doctorate in medicine and its applications in the Department of BIOCHEMISTRY and Microbiology is presented.



The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil)

The ability of tea tree oil to disrupt the permeability barrier of cell membrane structures and the accompanying loss of chemiosmotic control is the most likely source of its lethal action at minimum inhibitory levels.

Mechanism of Action of Melaleuca alternifolia (Tea Tree) Oil on Staphylococcus aureus Determined by Time-Kill, Lysis, Leakage, and Salt Tolerance Assays and Electron Microscopy

The predisposition to lysis, the loss of 260-nm-absorbing material, the lost of tolerance to NaCl, and the altered morphology seen by electron microscopy all suggest that tea tree oil and its components compromise the cytoplasmic membrane.

In vitro activity of Melaleuca alternifolia (tea tree) oil against bacterial and Candida spp. isolates from clinical specimens.

This study investigates the in vitro activity of tea tree oil against a range of wild strains of microorganisms isolated from clinical specimens of leg ulcers and pressure sores and finds that P. aeruginosa and the faecal streptococci isolates, with MICs and MBCs of >8%, were resistant to TTO.

Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream

After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group, and during follow‐up, no relapse occurred in cured patients and no improvement was seen in medication‐resistant and placebo participants.

Time-kill studies of tea tree oils on clinical isolates.

This study determined the kill rate of tea tree oil against several multidrug-resistant organisms, including MRSA, glycopeptide-resistant enterococci, aminoglycoside- resistant klebsiellae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, and also against sensitive microorganisms.

Australian tea tree oil – a natural antiseptic

  • Australian Journal of Biotechnology
  • 1989