Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta.

@article{Youssef2005AntimycobacterialSS,
  title={Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta.},
  author={Diaa T. A. Youssef and Lamiaa A Shaala and S. O. Emara},
  journal={Journal of natural products},
  year={2005},
  volume={68 12},
  pages={1782-4}
}
A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 microg/mL. Compound 2 displayed moderate inhibitory… CONTINUE READING

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