Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.

@article{Kobaisy1997AntimycobacterialPO,
  title={Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.},
  author={Mozaina Kobaisy and Zyta Abramowski and Leonard Lermer and Gaurav Saxena and Robert E W Hancock and G. H. N. Towers and Dan W. Doxsee and Richard W. Stokes},
  journal={Journal of natural products},
  year={1997},
  volume={60 11},
  pages={
          1210-3
        }
}
Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium… CONTINUE READING
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