Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10.

@article{Bottari2001AntimycobacterialIV,
  title={Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10.},
  author={Bruno Bottari and Rosanna Maccari and Francesca Monforte and Rosaria Ottan{\'a} and Enrico Rotondo and Maria Gabriella Vigorita},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 3},
  pages={301-3}
}
Octahedral cobalt(II) complexes of isonicotinoylhydrazones, which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.39 microg/mL, showing them to be generally more active than previously reported analogous Cu(II) and Ni(II) complexes.