Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class.

Abstract

Our work on antitubercular agents led to the identification of BM 212 as a lead compound among a series of pyrrole derivatives with good in vitro activity against mycobacteria and candidae. Further studies led us to synthesize additional pyrroles bearing the thiomorpholinomethyl moiety and different aryl substituents at N1 and C5. Some of them revealed very… (More)

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Cite this paper

@article{Biava2005AntimycobacterialCO, title={Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class.}, author={Mariangela Biava and Giulio Cesare Porretta and Giovanna Poce and Delia Deidda and Raffaello Pompei and Andrea Tafi and Fabrizio Manetti}, journal={Bioorganic & medicinal chemistry}, year={2005}, volume={13 4}, pages={1221-30} }