Antimycobacterial activity of chiral aminoalcohols with camphane scaffold.

@article{Petkova2014AntimycobacterialAO,
  title={Antimycobacterial activity of chiral aminoalcohols with camphane scaffold.},
  author={Zhanina Petkova and Violeta V Valcheva and Georgi Momekov and Petar Petrov and Vladimir Dimitrov and Irini A. Doytchinova and Georgi Stavrakov and Malinka Stoyanova},
  journal={European journal of medicinal chemistry},
  year={2014},
  volume={81},
  pages={150-7}
}
A series of aminoalcohols were synthesized by reaction of aminolysis of camphor derived oxiranes with chosen amines. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. Ten of the new structures show much higher activity than the classical anti-TB drug ethambutol. Some of the most active compounds were tested against MDR strain 43, and four of them demonstrated excellent activities with MICs 0.27-0.72 μM. The cytotoxicity of representative exerting… CONTINUE READING