Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium.

  title={Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium.},
  author={Tom{\'a}{\vs} Gichner and Gerassimos E Voutsinas and A Patrineli and A. Kappas and Michael J. Plewa},
  journal={Mutation research},
  volume={309 2},
The m-, o- and p-isomers of aminobenzoic acid (ABA) repressed the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. Their antimutagenic potency was in the order of o-ABA > m-ABA > p-ABA. The mechanism of this antimutagenicity is ascribed mainly to the decomposition of MNNG induced by the aminobenzoic acid isomers outside or within the bacterial cells. The inhibition of plant cell peroxidases and bacterial acetyltransferases that are required for the… CONTINUE READING